Phage Display-Directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication

(Mol Ther. 20, 2064–2075; November 1, 2012) Following publication of the article, authors realized that, in Figure 3a main manuscript and Supplementary S5, errors occurred presentation western blot images splicing was not indicated both figures respective figure legends. To correct errors, have provided a new file for based on single experiment blot. The data do affect any means results conclusions as published initial manuscript. For S5 without splicing. Again, representation does conclusion results. legends require change. regret these errors.Figure S5Characterization different cell lines stably expressing cyclic peptides (CPs)View Large Image ViewerDownload Hi-res image Download (PPT) Phage Display-directed Discovery LEDGF/p75 Binding Cyclic Peptide Inhibitors HIV ReplicationDesimmie et al.Molecular TherapyNovember, 2012In BriefThe interaction between human immunodeficiency virus (HIV) integrase (IN) its cellular cofactor lens epithelium-derived growth factor (LEDGF/p75) is crucial replication. While recently discovered LEDGINs inhibit HIV-1 replication by occupying pocket IN, it remained to be demonstrated whether itself can targeted. By phage display we identified (CPs) first ligands that LEDGF/p75–IN interaction. CPs overt toxicity. Full-Text PDF Open Archive